Low Dose Oxybutin in Primary Hyperhydrosis: A Prospective Study from a Tertiary Care Center in Nepal

Introduction: Hyperhydrosis is a clinical condition where there excessive sweating beyond the physiological need of patient’s body. This can directly or indirectly affect quality patients life. Oxybutin widely used in urology as anticholinergic medication for bladder urge incontinence. It be safely at high doses (over 15 mg/day) to treat urological disorder. also acts against and cases hyperhidrosis. Objectives: To evaluate effectiveness oxybutin low dose assess Hyperhidrosis Disease Severity Scale (HDSS) . Materials Methods: hospital based cross-sectional study primary hyperhydrosis. was prescribed all hyperhydrosis with gradual increment dosage 2.5 mg orally once day 5 twice day. Patients were evaluated zero wk (baseline), 4 wk, 8 12 follow-up 16 wks along adverse effects noted. Results: There significant difference HDSS (baseline) 4th (p=0.001) oxybutynin. Also, noted (p=0.022) between wk. Similarly, versus 16th Conclusion: an drug emerging role Low have shown results minimal side effects. The requirement varies among authors. Studies long-term follow-ups ideal protocol established future.